Cardiovascular System

Overview: The Cardiovascular System & Biomunity™

The cardiovascular system has 3 main components; the heart, blood, and the vascular system of vessels that carry blood throughout our bodies. Disorders of the heart and blood vessels are collectively referred to as Cardiovascular diseases (CVD). Increasing evidence suggests a strong correlation between dysbiosis in the gut microbiome and progression of cardiovascular diseases. Several studies have demonstrated a relationship between the gut microbial environment and diseases such as coronary artery disease and heart failure, and modulation of the gut microbiome as a therapeutic strategy for addressing—and arresting, if not reversing, the progress---of CVD are gaining interest within the scientific community. [1]

 

Biomunity™ Can Help

Strategies which modulate the gut microbiota are emerging as effective tools for reducing CVD risk. These are based on the recognition that a healthy gut microbiota may reduce CVD risk factors and encourage a healthy heart. [2]  Since major risk factors for CVD, such as dietary choices and habits, are initially experienced in the gut microbiome, it is not difficult to see the gut microbiota as a novel regulator of cardiovascular function and disease. [3]

The Science

External factors can alter composition of the microbiota, which affects susceptibility of most chronic diseases, including cardiovascular diseases (CVD).  The link between the microbiota and disease processes is mediated by microbial metabolites and bacterial components that enter general circulation and interact directly with cardiovascular tissues, as well as other metabolic tissues that can alter cardiovascular function.

Battson ML, Lee DM, Weir TL, Gentile CL. The gut microbiota as a novel regulator of cardiovascular function and disease. J Nutr Biochem. 2018 Jun;56:1-15. doi: 10.1016/j.jnutbio.2017.12.010. Epub 2017 Dec 27. PMID: 29427903.

Specific Ingredients that Help

Lactobacillus acidophilis and Bifidobacterium lactis can downregulate serum total cholesterol (TC) level and reduce cholesterol absorption. [4]

 

Lactobacillus plantarum is able to reduce TC levels, and to survive the environment of acid or bile and colonize easily in the human intestine. [4] 

 

CoQ10 may play a beneficial role as a supplemental therapy in different cardiac conditions.  CoQ10 deficiency is also associated with certain cardiovascular diseases, such as atherosclerosis, hypertension, and dyslipidemia. [5]

 

Beta Glucans intake is beneficial in the prevention, treatment, and control of cardiovascular diseases, due to their ability to attenuate blood postprandial glycemic and insulinemic responses. [6]

 

Vitamin D insufficiency has been associated with a risk of CVD, increasing the risk for incidents of hypertension, ischemic heart disease (IHD), sudden cardiac death, or heart failure. [7]

References:

  1. Yoshida N, Yamashita T, Hirata KI. Gut Microbiome and Cardiovascular Diseases. Diseases. 2018;6(3):56. Published 2018 Jun 29. doi:10.3390/diseases6030056
  2. Tuohy KM, Fava F, Viola R. 'The way to a man's heart is through his gut microbiota'--dietary pro- and prebiotics for the management of cardiovascular risk. Proc Nutr Soc. 2014 May;73(2):172-85. doi: 10.1017/S0029665113003911. Epub 2014 Feb 4. PMID: 24495527. 
  3. Battson ML, Lee DM, Weir TL, Gentile CL. The gut microbiota as a novel regulator of cardiovascular function and disease. J Nutr Biochem. 2018 Jun;56:1-15. doi: 10.1016/j.jnutbio.2017.12.010. Epub 2017 Dec 27. PMID: 29427903. 
  4. Wang L, Guo MJ, Gao Q, et al. The effects of probiotics on total cholesterol: A meta-analysis of randomized controlled trials. Medicine (Baltimore). 2018;97(5):e9679. doi:10.1097/MD.0000000000009679
  5. Zozina VI, Covantev S, Goroshko OA, Krasnykh LM, Kukes VG. Coenzyme Q10 in Cardiovascular and Metabolic Diseases: Current State of the Problem. Curr Cardiol Rev. 2018;14(3):164-174. doi:10.2174/1573403X14666180416115428
  6. Daou, C. and Zhang, H. (2012), Oat Beta‐Glucan: Its Role in Health Promotion and Prevention of Diseases. Comprehensive Reviews in Food Science and Food Safety, 11: 355-365. https://doi.org/10.1111/j.1541-4337.2012.00189.x
  7. Judd SE, Tangpricha V. Vitamin D deficiency and risk for cardiovascular disease. Am J Med Sci. 2009;338(1):40-44. doi:10.1097/MAJ.0b013e3181aaee91