Metabolic System

Overview: The Metabolic System & Biomunity™

The gut-brain-axis transmits information from organs, such as the intestine, to the brain which uses this information to regulate energy utilization and storage.  The gut microbiota governs our ability to harvest energy from food and produces metabolites (short-chain fatty acids) which act as signaling molecules that modulate appetite, energy uptake and storage, and energy expenditure.  Besides being an energy source, these SCFAs also play a major role in energy homeostasis. [1] 

Evidence also supports the role of the human gut microbiota in weight management. Diets that are high in fat and refined carbohydrates, which are common in Western civilization, promote increased intestinal bacteria linked to obesity.  Research findings in this field indicate that manipulating the gut microbiota could facilitate weight loss. [2]

Biomunity™ Can Help

Biomunity can help modulate energy production and reduce fatigue and tiredness over time.  The Biomunity formula includes essential nutrients that directly impact physical functional health.  

Targeting the microbiota, through dietary supplementation, offers an avenue for intervening to prevent obesity and associated metabolic disorders.  Research has shown that gut microbiome-modulating dietary agents (including prebiotics, probiotics, and synbiotics) can aid in decreasing BMI, weight, and fat mass.[3]

The Science

The gut microbiota has emerged as an environmental factor that modulates energy supply. It increases the host’s ability to harvest energy from digested food, and produces metabolites and microbial products (such as short-chain fatty acids) which act as signaling molecules that modulate appetite, gut motility, energy uptake and storage, and energy expenditure.

Heiss CN, Olofsson LE. Gut Microbiota-Dependent Modulation of Energy Metabolism. J Innate Immun. 2018;10(3):163-171. doi: 10.1159/000481519. Epub 2017 Nov 8. PMID: 29131106; PMCID: PMC6757175.  https://pubmed.ncbi.nlm.nih.gov/29131106/

Evidence suggests that there is a link between metabolic diseases and bacterial populations in the gut.  Results of this study indicate that type 2 diabetes in humans is associated with compositional changes in intestinal microbiota.

Larsen N, Vogensen FK, van den Berg FW, Nielsen DS, Andreasen AS, Pedersen BK, Al-Soud WA, Sørensen SJ, Hansen LH, Jakobsen M. Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults. PLoS One. 2010 Feb 5;5(2):e9085. doi: 10.1371/journal.pone.0009085. PMID: 20140211; PMCID: PMC2816710. https://pubmed.ncbi.nlm.nih.gov/20140211/ 

Specific Ingredients that Help

Bifidobacterium Lactis can slow down detrimental processes associated with metabolic edotoxemia (imbalanced state) via multiple signaling pathways.  Research further indicates that B. Lactis may improve epithelial integrity by rebalancing a dysbiotic state induced by an obesogenic diet. [4][5]

 

CoQ10 has properties related to bioenergetic and antioxidant activity; thus, it is intimately involved in energy production. [6]

 

Vitamin D3 treatment has been shown to improve fatigue in otherwise healthy persons with Vitamin D deficiency. [7]

 

CurQFen has been shown to reduce fatigue and tiredness over time. [8]

 

Cinnamon supplementation can help to lower body weight and body mass index (BMI). [9]

 

References:

  1. Riedl RA, Atkinson SN, Burnett CML, Grobe JL, Kirby JR. The Gut Microbiome, Energy Homeostasis, and Implications for Hypertension. Curr Hypertens Rep. 2017;19(4):27. doi:10.1007/s11906-017-0721-6 
  2. Davis CD. The Gut Microbiome and Its Role in Obesity. Nutr Today. 2016;51(4):167-174. doi:10.1097/NT.0000000000000167
  3. John GK, Wang L, Nanavati J, Twose C, Singh R, Mullin G. Dietary Alteration of the Gut Microbiome and Its Impact on Weight and Fat Mass: A Systematic Review and Meta-Analysis. Genes (Basel). 2018;9(3):167. Published 2018 Mar 16. doi:10.3390/genes9030167
  4. Uusitupa HM, Rasinkangas P, Lehtinen MJ, Mäkelä SM, Airaksinen K, Anglenius H, Ouwehand AC, Maukonen J. Bifidobacterium animalis subsp. lactis 420 for Metabolic Health: Review of the Research. Nutrients. 2020 Mar 25;12(4):892. doi: 10.3390/nu12040892. PMID: 32218248; PMCID: PMC7230722. 
  5. Mazloom K, Siddiqi I, Covasa M. Probiotics: How Effective Are They in the Fight against Obesity?. Nutrients. 2019;11(2):258. Published 2019 Jan 24. doi:10.3390/nu11020258 
  6. Sarmiento A, Diaz-Castro J, Pulido-Moran M, Kajarabille N, Guisado R, Ochoa JJ. Coenzyme Q10 Supplementation and Exercise in Healthy Humans: A Systematic Review. Curr Drug Metab. 2016;17(4):345-58. doi: 10.2174/1389200216666151103115654. PMID: 26526835.
  7. Nowak A, Boesch L, Andres E, et al. Effect of vitamin D3 on self-perceived fatigue: A double-blind randomized placebo-controlled trial [published correction appears in Medicine (Baltimore). 2017 Jan 20;96(3):e6038]. Medicine (Baltimore). 2016;95(52):e5353. doi:10.1097/MD.0000000000005353
  8. Khanna A, Das S S, Kannan R, Swick AG, Matthewman C, Maliakel B, Ittiyavirah SP, Krishnakumar IM. The effects of oral administration of curcumin-galactomannan complex on brain waves are consistent with brain penetration: a randomized, double-blinded, placebo-controlled pilot study. Nutr Neurosci. 2020 Dec 9:1-10. doi: 10.1080/1028415X.2020.1853410. Epub ahead of print. PMID: 33295851. 
  9. Mousavi SM, Rahmani J, Kord-Varkaneh H, Sheikhi A, Larijani B, Esmaillzadeh A. Cinnamon supplementation positively affects obesity: A systematic review and dose-response meta-analysis of randomized controlled trials. Clin Nutr. 2020 Jan;39(1):123-133. doi: 10.1016/j.clnu.2019.02.017. Epub 2019 Feb 15. PMID: 30799194.